【English CV】

Name: Ji Hshiung Chen

Tel: 886-3-8565301 ext. 2661、2664

Fax: 886-3-8578386

E-mail: jhc@mail.tcu.edu.tw

Education :

Position :

St. Jude Children’s Research Hospital, Memphis, TN U.S.A	Tumor Biology	Assistant Member	1983/09 ~ 1988/08
M.D. Anderson Cancer Center, Houston, Texas	Exp Pediatrics Molecular Genetics	Associate Professor	1988/09 ~ 1993/10
Institut Pasteur de Lille	Oncologic Moleculaire	Visiting Professor	1993/11~ 1995/08
Tzu Chi College of Medicine	Molecular Biology	Professor	1995/08 ~ 1999/08
Tzu Chi College of Medicine and Humanity	Institute of Medical Science	Director	1996/08 ~ 2000/07
Tzu Chi University	College of Life Science	Dean	2000/08 ~ 2002/07
Tzu Chi University	Institute of Human Genetics	Director	2003/08 ~ 2004/07
Tzu Chi University	Institute of Molecular and Cell Biology	Professor / Director	1999/08 ~ 2008/07
Tzu Chi University	Department of Molecular Biology and Human Genetics	Professor / Chairman	2008/08 ~ Present

Publication:

(1) Ru, H. Y., Chen, R. L., Lu, W. C., Chen, J. H. (2002) hBUB1 defects in leukemia and lymphoma cells. Oncogene 21: 4673-4679.

(SCI) (NSC89-2320-B-320-017)

(2) Chen, J. H. (2002) Tumor Invasion and Metastasis. Tzu Chi Med. J. 14: 1-5. (NSC88-2314-B-320-009)

(3) Liu, H-T., Lin, T-H., Kuo, H-C., Chen, Y-C., Tsay, H-J., Jeng, H-H., Tsai, P-C., Shie, F-K., Chen, J-H and Huang, H-B. (2002)

Identification of the Alternative Splice Products Encoded by the Human Protein Phosphatase Inhibitor-1 Gene.

BBRC 291: 1293-1296. (SCI)

(4) Lu, W. C., Liu, Y. N., Kang, B. B., Chen, J. H. (2003) Trans-activation of heparanase promoter by ETS transcription factor.

Oncogene 22: 919-923. (NSC88-2314-B-320-009、NSC89-2318-B-320-003-M51) (SCI)

(5) Liu, Y. N., Kang, B. B., Chen, J. H. (2004) Transcriptional regulation of human Osteopontin promoter by C/EBPα and AML-1

in metastatic cancer cells. Oncogene 23: 278-288. (NSC92-2320-B-320-027) (SCI)

(6) Liu, Y. N., Lee, W. W., Wang, C. Y., Chao, T. H., Chen, Y. V. and Chen, J. H. (2005) Regulatory mechanisms controlling

human E-cadherin gene expression. Oncogene 24:8277-8290. (NSC91-2745-B-320-001、NSC91-2320-B-320-012) (SCI)

(7) Hsu, Y. M., Chen, Y. F., Chou, C. Y., Tang, M. J., Chen, J. H., Wilkins, R. J., Ellory, J. C., Shen, M. R. (2007)

KCI Cotransporter-3 Down-regulates E-Cadherin/b-Catenin Complex to Promote Epithelial-Mesenchymal Transition.

Cancer Res. 67(22):11064-11073.

(8) Vesuna, F., van Diest, P., Chen, J. H., Raman, V. (2008) Twist is a transcriptional repressor of E-cadherin gene expression

in breast cancer. BBRC. 367: 235-241.

(9) M Botlagunta, F Vesuna, Y Mironchik, A Raman, A Lisok, P Winnard Jr, S Mukadam, P Van Diest, JH Chen, P Farabaugh,

AH Patel and V Raman. (2008) Oncogenic role of DDX3 in breast cancer biogenesis. Oncogene 1:1-11.

(10) Liu, Y. N., Liu, Y., Chen, J. H. (2008) Activated estrogen receptor a (ERa ) down-regulates human E-cadherin gene expression.

Cancer Res. (In revision)

(11) Liu, Y. N., Liu, Y., Lee, H. J., Hsu, Y. H., Chen, J. H. (2008) Activated androgen receptor downregulates E-cadherin gene

expression and promotes tumor metastasis. Mol. Cell Biol. 28:7096-7108.